Semaglutide
- Formula
- C187H291N45O59
- Molecular weight
- 4114 g/mol
- CAS
- 910463-68-2
- PubChem CID
- 56843331 ↗
SteroidsCanada.orgPeptideSKU SM5-5MG
SM5 5mg
Semaglutide · Lyophilized powder (vial)
5.0 from 6 reviews$150CAD
In stock, ships from VancouverStrength5 mg per vial
Pack1 vial
Total per order5 mg
Half-life≈ 7 days
Add $150 more for free Xpresspost.
You will need to mix and measure it
- Delivery guaranteeLost or seized: reshipped free
- Tracking in 72 hPacked in Vancouver
- Interace-TransferFrom any Canadian bank
- Plain packagingNo product names outside
Overview
SM5 is the store’s name for semaglutide, a long-acting GLP-1 receptor agonist. In Canada it is a prescription medicine for type 2 diabetes and for weight management.
How it works
It mimics the gut hormone GLP-1: it slows stomach emptying, increases insulin release when blood sugar is high and acts on appetite centres in the brain. A fatty side chain lets it bind albumin, which stretches its half-life to about a week.
Chemistry
From PubChem, the US National Library of Medicine’s chemistry database.
Clinical reference
Health Canada’s weight-management labelling starts at 0.25 mg once a week for four weeks, then steps up every four weeks (0.5, 1, 1.7 mg) to a maintenance amount of 2.4 mg a week. Diabetes labelling stops at 2 mg a week.
Label and guideline amounts are shown for reference only. They are not a recommendation, and we never give cycle or performance amounts. Any use belongs under a doctor’s care, with bloodwork.
Measuring calculator
Converts an amount you enter into what to measure. It does not suggest an amount.
Strength used: 5 mg per vial
Injection sites
SM5 5mg is a freeze-dried powder. After mixing with bacteriostatic water, compounds like this are usually injected subcutaneously (subQ): into the fat just under the skin with a short insulin needle.
- Volume per site
- About 1 ml or less
- Needle
- 4 to 13 mm insulin needle, 29 to 31G
Finding it. Anywhere on the belly at least 5 cm from the navel, avoiding scars and the belt line. Pinch a fold of skin and inject into it.
Why it is used. The most-used subcutaneous site: easy to see, plenty of fat and steady absorption. Weekly GLP-1 pens list it first.
Watch out. Move each injection 2 to 3 cm from the last to avoid hard lumps.
- Volume per site
- About 1 ml or less
- Needle
- 4 to 13 mm insulin needle, 29 to 31G
Finding it. The middle of the front of the thigh, a hand-width below the hip and a hand-width above the knee.
Why it is used. Easy to reach seated and a good second site to rotate with the belly.
Watch out. Absorption can be a little slower than the belly.
- Volume per site
- About 1 ml or less
- Needle
- 4 to 13 mm insulin needle, 29 to 31G
Finding it. The fleshy back of the upper arm, halfway between shoulder and elbow.
Why it is used. A third site to rotate through so each spot rests longer.
Watch out. Hard to pinch and reach on yourself; a helper makes it easier.
Why these sites for SM5 5mg
Subcutaneous (subQ)- Belly first. The abdomen has the most fat and the steadiest absorption, and you can see what you are doing.
- Short needle, small volume. About 1 ml or less per spot with an insulin syringe. Pinch the skin if you are lean.
- Move every time. Keep each injection 2 to 3 cm from the last to avoid lumps.
Every time: wash your hands, wipe the vial stopper and skin with alcohol, use a new sterile needle and syringe, and never share. See a doctor for spreading redness, heat, swelling, pus, fever or numbness. This is general guidance from standard nursing practice, not medical advice; a pharmacist or nurse can show you in person.
Combinations and interactions
Prescribed or used alongside
- Bacteriostatic water to mix the powder and U-100 insulin syringes to measure it.
- In practice it is prescribed alongside diet and activity changes, not combined with other GLP-1 class drugs.
Drug interactions
- Insulin and sulfonylureas: higher risk of low blood sugar.
- Oral medicines: slower stomach emptying can change how fast pills are absorbed.
Risks and bloodwork
Nausea and stomach upset
The most common effects, mostly when the amount is increased.
Pancreatitis
Rare; severe stomach pain that spreads to the back needs urgent care.
Gallbladder
Rapid weight loss increases gallstone risk.
Thyroid
Not used by people with a personal or family history of medullary thyroid cancer.
Bloodwork doctors check
- Fasting glucose and HbA1c
- Kidney function (creatinine, eGFR)
- Lipase if stomach pain appears
- Resting heart rate
- Weight and waist measurements
Not for
People under 18, anyone pregnant or breastfeeding, anyone with active cancer or a history of cancer, and anyone with diabetes unless a doctor is involved.
Canadian legal status
In Canada this is a prescription drug under the Food and Drugs Act. Using it under a doctor’s care, with bloodwork, is how it is meant to be used. This is general information, not legal advice.
References
- Once-Weekly Semaglutide in Adults with Overweight or ObesityWilding JPH et al. · N Engl J Med, 2021 · PMID 33567185
- Safety of SemaglutideSmits MM, Van Raalte DH · Front Endocrinol (Lausanne), 2021 · PMID 34305810
- Acute pancreatitis due to different semaglutide regimens: An updated meta-analysisMasson W et al. · Endocrinol Diabetes Nutr (Engl Ed), 2024 · PMID 38555109
Reviews
5.06 reviews from customers
Reviews are published after a quick check. Only customers who bought this product can review it.
Rated without a written review.
Reply from SteroidsCanada.org
Enrique, thank you for coming back for more SM5!
Fast delivery.
Reply from SteroidsCanada.org
Thank you! We're glad your SM5 arrived quickly. Reach out if you have any questions.
So far so good. No complaints. I was worried it might be under dosed but it's not. Good stuff. Great seller. Fast delivery.
Reply from SteroidsCanada.org
Marek, thank you for the honest review! Clear labelling and accurate dosing matter to us, so we're glad it met your expectations.
Rated without a written review.
Reply from SteroidsCanada.org
Enrique, thank you for the five stars on the SM5! Keep protein high and stay hydrated.
Great product! Ordering was easy and delivery was fast. Will absolutely order products from this site again!
Reply from SteroidsCanada.org
Susan, thank you so much! We're glad ordering felt easy and delivery was quick. We'll be happy to help with your next order. Remember to keep protein high while on SM5.
Great product
Reply from SteroidsCanada.org
Thanks, Brett! We're glad you were happy with the SM5. Keep protein high and stay hydrated, and reach out if you have questions.
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FAQ
Why is it called SM5?
SM5 is the store’s product name for this GLP-1 research peptide.
How long does it last?
About seven days, which is why the clinical schedule is weekly.
What do I need with it?
Bacteriostatic water and U-100 insulin syringes.
How fast will it arrive?
Orders ship from Vancouver by Canada Post Xpresspost. You get a tracking number within 72 hours of payment; delivery then takes 1 to 2 business days in BC, 3 to 4 in Ontario and 3 to 5 in Quebec.
What if my parcel is lost or seized?
We reship it free. Contact us with your order number.
Adults 18+. This page is general information, not medical advice. Talk to a licensed healthcare provider before using any compound.
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