Letrozole, an aromatase inhibitor, is the most widely used drug for breast cancer in the mastectomized female. It is most often combined with another agent to prevent the development of resistance. Cyproterone acetate, a progestin, has been used to prevent estrogen synthesis in the breast. It is usually combined with tamoxifen. Aromatase inhibitors work by blocking the production of estrogen in the body.
Letrozole is an aromatase inhibitor indicated for the treatment of breast cancer in postmenopausal women. It is also used to treat postmenopausal women with hormone-receptor-positive metastatic breast cancer who have received prior endocrine therapy. Letrozole is usually administered as adjuvant therapy for 5 years in patients with node-positive breast cancer.
Letrozole can lower your sperm count. This effect can last longer than the treatment with letrozole.
You may take letrozole with or without food. If you need surgery or medical tests, tell the surgeon or doctor ahead of time that you are using letrozole. You may need to stop using the medicine for a short time.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.
What should I avoid while taking letrozole? Do not drink alcohol. Dangerous side effects could occur. Grapefruit and grapefruit juice may interact with letrozole and lead to unwanted side effects. Avoid the use of grapefruit products while taking letrozole.