Zionova Aromasin 20mg
Exemestane, sold under the brand name Zionova Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Exemestane is a steroidal aromatase inhibitor which prevents the production of estrogen.
Mechanism of action
Exemestane is an irreversible, steroidal aromatase inhibitor (type II). It is the first steroidal aromatase inhibitor to be marketed.
It works by binding permanently to the aromatase enzyme, which is responsible for the conversion of androgens to estrogens.
Exemestane has approximately 1000 times the binding affinity to the aromatase enzyme than tamoxifen and approximately 10,000 times the binding affinity of anastrozole.
Without the enzyme, the conversion of androgens to estrogens cannot occur. Exemestane is therefore presented as a very effective treatment for breast cancer.
Exemestane inhibits the estradiol production in the adrenal glands, which eventually leads to a decrease in ovarian estradiol production.
Exemestane also induces apoptosis, arrests cell cycle progression at the G2/M phase and dramatically inhibits the growth of human breast cancer cells in vitro.
Zionova Aromasin may be used to treat advanced breast cancer in postmenopausal women.
It may also be used to treat advanced breast cancer in postmenopausal women with hormone-receptor positive, HER2-negative breast cancer who have received at least one chemotherapy treatment.It may also be used to treat hormone-receptor positive, HER2-negative advanced breast cancer in postmenopausal women who have received at least two chemotherapy treatments.
Zionova Aromasin is available in 20 mg tablets, which are to be taken once daily.
Aromasin is usually taken on an empty stomach around the same time each day.
Aromasin may be taken with or without food.
The dosage of Aromasin is based on the medical condition being treated, age, weight, laboratory tests and response to treatment.
Store at room temperature away from moisture, heat and light. Keep out of reach of children.
5 reasons to use Zionova Aromasin
- Aromasin is an aromatase inhibitor, which means it helps to prevent the production of estrogen in the body. This can be helpful for people who are at risk for estrogen-related side effects, such as gyno or breast cancer.
- Aromasin can help to improve bone density and reduce the risk of osteoporosis.
- Aromasin can help to reduce the risk of cardiovascular disease.
- Aromasin can help to improve mental clarity and focus.
- Aromasin is a safe and effective treatment for hot flashes and other menopausal symptoms.