NPP

$90.00

Nandrolone is a substrate for the enzyme 5α-reductase. 5α-Reductase metabolizes nandrolone into the potent AR agonist mestanolone (17α-methyl-DHT) and the weaker AR agonist 5α-dihydronandrolone (5α-DHN; androstanolone). These metabolites of nandrolone are androgenic precursors to 5α-DHT and estrogens via aromatization and may be involved in certain effects associated with nandrolone use, such as body hair growth.
 
They may also have weak androgenic activity and contribute to nandrolone’s overall androgenicity. Nandrolone is also metabolized by aromatase into estradiol and estrone, and by 5β-reductase into 5β-DHT. The 5β-DHT metabolite may have some androgenic activity. Nandrolone is also a substrate for glucuronidation, sulfation, and hydroxylation via cytochrome P450 enzymes such as CYP2C9 and CYP3A4.
 
Nandrolone, also known as 19-nortestosterone (19-NT) or as estrenolone, as well as estra-4-en-17β-ol-3-one or 4-estren-17β-ol-3-one, is a naturally occurring estrane (C18) steroid and an endogenous progestogen and androgen or anabolic steroid hormone. It is the C19 demethylated (nor) analogue of testosterone (testosterone is converted to nandrolone by demethylation at the C19 position). Relative to testosterone, nandrolone has reduced methylation at carbon atom C4, which in turn results in altered metabolism of the drug by liver microsomes and cytochrome P450 (CYP) enzymes.
 
The elimination half-life of nandrolone under normal conditions is 6 hours. Nandrolone was synthesized in 1950 and was first introduced for medical use in 1955. It was developed by Organon International from the late 1940s to the early 1950s. Organon’s original patent on nandrolone has expired in most countries; however, Organon still retains patent rights for some countries. Nandrolone’s introduction preceded that of other commercially successful anabolic steroids such as methandrostenolone (1962), methyltestosterone (1963), methenolone (1963), and fluoxymesterone (1964). Nandrolone was the first commercially available AAS in the United States.

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Nandrolone phenylpropionate
NPP

$90.00

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