Nandrolone phenylpropionate


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Nandrolone is a substrate for the enzyme 5α-reductase. 5α-Reductase metabolizes nandrolone into the potent AR agonist mestanolone (17α-methyl-DHT) and the weaker AR agonist 5α-dihydronandrolone (5α-DHN; androstanolone). These metabolites of nandrolone are androgenic precursors to 5α-DHT and estrogens via aromatization and may be involved in certain effects associated with nandrolone use, such as body hair growth.
They may also have weak androgenic activity and contribute to nandrolone’s overall androgenicity. Nandrolone is also metabolized by aromatase into estradiol and estrone, and by 5β-reductase into 5β-DHT. The 5β-DHT metabolite may have some androgenic activity. Nandrolone is also a substrate for glucuronidation, sulfation, and hydroxylation via cytochrome P450 enzymes such as CYP2C9 and CYP3A4.
Nandrolone, also known as 19-nortestosterone (19-NT) or as estrenolone, as well as estra-4-en-17β-ol-3-one or 4-estren-17β-ol-3-one, is a naturally occurring estrane (C18) steroid and an endogenous progestogen and androgen or anabolic steroid hormone. It is the C19 demethylated (nor) analogue of testosterone (testosterone is converted to nandrolone by demethylation at the C19 position). Relative to testosterone, nandrolone has reduced methylation at carbon atom C4, which in turn results in altered metabolism of the drug by liver microsomes and cytochrome P450 (CYP) enzymes.
The elimination half-life of nandrolone under normal conditions is 6 hours. Nandrolone was synthesized in 1950 and was first introduced for medical use in 1955. It was developed by Organon International from the late 1940s to the early 1950s. Organon’s original patent on nandrolone has expired in most countries; however, Organon still retains patent rights for some countries. Nandrolone’s introduction preceded that of other commercially successful anabolic steroids such as methandrostenolone (1962), methyltestosterone (1963), methenolone (1963), and fluoxymesterone (1964). Nandrolone was the first commercially available AAS in the United States.

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    Nandrolone phenylpropionate or nandrolone phenpropionate sold under the brand name Durabolin among others is an androgen and anabolic steroid Nandrolone phenylpropionate, also known as nandrolone phenylpropionate, is a synthetic androgen and anabolic steroid and a nandrolone ester. Nandrolone phenylpropionate, when administered via intramuscular injection, has an active life of approximately 3 to 5 days. Durabolin is almost always sold in its esterified form, either as nandrolone phenylpropionate or as nandrolone decanoate.

    Nandrolone phenylpropionate is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters. It is a popular steroid for strength and size gains, particularly among users interested in increasing muscle mass and performance without adding much body fat. As it is anabolic, it can also be used to increase muscle mass and performance in hypogonadal men (e.g. in the treatment of HIV AIDS). Nandrolone phenylpropionate is generally stacked with other anabolic agents, such as testosterone, methenolone, or oxandrolone. Nandrolone is also sometimes stacked with non-steroidal agents such as trenbolone or stanozolol.

    Nandrolone phenylpropionate is available in injectable form. the injectable is sold as Deca-Durabolin, Durabolin S, and many others. Nandrolone is an androgen and anabolic steroid or an agonist of the androgen receptor (AR). It is structurally related to dihydrotestosterone (DHT), with two of the four methyl groups on the DHT molecule replaced with a phenyl group. As a result of this alteration, nandrolone has diminished androgenic potency relative to DHT. Relative to testosterone (T), nandrolone has a somewhat reduced affinity for androgen receptors but nonetheless has strong androgenic activity. The potency of nandrolone and its derivatives as anabolic agents is considered to be at least equal to that of testosterone and greater than that of DHT.

    Like other AAS, nandrolone has been reported to augment levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the body. It is inhibitory of testosterone production in the testes, thus reducing levels of this hormone in plasma. This effect may be especially pronounced when the drug is administered along with testosterone, a combination that causes a reduction of testosterone production of up to 70%. Nandrolone may inhibit the enzyme aromatase, which converts androgens into estrogens (via estradiol). As a result, nandrolone may decrease estrogen levels in the body. Nandrolone has also been shown to suppress levels of corticosteroid-binding globulin (CBG), a protein that reduces the activity of glucocorticoids in the body. The pharmacokinetics of nandrolone have been investigated. Nandrolone is metabolized by the body into various inactive metabolites. The elimination half-life of nandrolone is reported to be approximately 6 hours under normal conditions, with about 95% of a dose being excreted within 72 hours of administration.

    Additional information

    Weight 0.1 kg
    Dimensions 1 × 1 × 1 cm


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